Resident Evil 4 Remake Best Weapons [Top 7]

Equip Leon with the best guns in Resident Evil 4 to survive the Ganados plague & save Ashley!

Resident Evil 4 Remake is packed with some of the best weapons from the series. You have the option of selecting the best guns out of 29 firearms in the game, which speaks volumes about how much versatility you can add to combat. While not all guns perform equally, and every weapon comes with a set of pros and cons, learning about the best ones is the key to survival in the Ganados plague.

Resident Evil 4 Remake features 29 Weapons for players to unlock. If you acquire all weapons in RE4 Remake, you will unlock the Gun Fanatic trophy/achievement. Here are all the Best Weapons in RE4 Remake compared to each other in the table below:

WeaponsTypeBest ForPower (Max)Ammo (Max)Reload Speed (Max)Rate of FirePrecision
Red9Semi Auto HandgunThe Best Handgun In Resident Evil 4 Remake2.716.01.251.264.8
PunisherSemi Auto HandgunThe Fastest Reload Speed In Handguns1.924.01.51.914.5
MatildaHandgunThe Highest Fire Rate In Handguns2.070.00.932.53.0
W-870ShotgunThe Best Shotgun For Early Game10.1 x 210.00.950.852.8
Killer7MagnumThe Highest Base Dmg In Magnums28.015.01.41.162.5
Bolt ThrowerSpecialThe Best Stealth Weapon In The Game2.410 x 20.940.853.0
Fighting KnifeMeleeThe Best Knife In Resident Evil 4 Remake1.80.00.00.00.0

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1. Red9

The Best Handgun In Resident Evil 4 Remake.
Red9
StatsDescription
Power2.70
Ammo Capacity16
Reload Speed1.25
Rate of Fire1.26
Precision4.80
  • Why I Chose This: Red9 can deal with the highest DMG in handguns, has balanced stats, and can be acquired quite early, making it the best handgun.
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Starting off my Resident Evil 4 Remake Best Weapons list, the Red9 handgun has undoubtedly earned its reputation as one of the best weapons. Its unrivaled power, surpassing all other non-magnum handguns, is a testament to its supremacy. Upon acquiring the Red9, you may initially be put off by its unwieldy recoil and lackluster accuracy.

  • However, these shortcomings can be overcome by investing in indispensable stock attachments.
  • This upgrade transforms the Red9 into a formidable weapon, justifying the price and inventory space it requires.
  • Remember, though, that the stock isn’t immediately available from the vendor, so persistence and patience are key to unlocking the full potential of this powerhouse handgun.
  • Has high accuracy, low recoil, and the highest DMG in handguns.
  • Possesses an exclusive upgrade that further increases the dmg multiplier. 
  • The stock attachments are necessary and require a lot of space.
  • The stocking is available late and requires money to buy.

2. Punisher

The Fastest Reload Speed In Handguns.
Punisher
StatsDescription
Power1.90
Ammo Capacity24
Reload Speed1.50
Rate of Fire1.91
Precision4.50
  • Why I Chose This: Punisher is very precise and has a unique passive that allows it to strike through upto five targets, making it an ideal choice for crowd-control.
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The Punisher handgun holds its own in the remake, despite some shortcomings. While the SG-09 R may boast slightly better stats and raw damage, the Punisher’s true value lies in its penetration power, allowing you to eliminate multiple enemies with a single shot if they’re properly aligned.

  • This distinctive feature is further enhanced by the Exclusive upgrade, which increases penetration 5x, making the Punisher an indispensable crowd-clearing weapon.
  • Complemented by a relatively low upgrade cost, swift firing rate, and rapid reload time.
  • The Punisher’s 9mm semi-automatic design offers a unique advantage in the arsenal of handguns, even though it may not pack the most powerful punch.
  • Can pierce through enemies by unlocking the passive.
  • Acquired very early and remains good for most situations.
  • Deals low DMG and thus requires upgrading.
  • Has high recoil and relatively low fire rate.

3. Matilda

The Highest Fire Rate In Handguns.
Matilda
StatsDescription
Power2.00
Ammo Capacity70
Reload Speed0.93
Rate of Fire2.50
Precision3.00
  • Why I Chose This: Matilda has the ability to shoot multiple shots in one go that can deal a ton of dmg overtime, making it a viable option for boss fights.
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Next, in my best re4 weapons, I have the Matilda. Paying homage to Resident Evil 2, the Matilda is a three-round burst pistol that bridges the gap between traditional handguns and SMGs. While its firepower ranks in the middle amongst its handgun counterparts, it boasts the quickest rate of fire, reload speed and largest capacity.

  • These attributes are further enhanced when a stock is attached, transforming the Matilda into an even more efficient and deadly weapon.
  • However, it’s important to note that the Matilda has a hefty price tag for full upgrades.
  • Despite this, Matilda’s unique features and versatility make it a valuable asset in the hands of skilled players.
  • Shoots multiple shots, ideal for boss fights.
  • Has high reload speed and large ammo capacity.
  • It uses plenty of ammo but needs to be used carefully.
  • High recoil due to multiple shots and high fire rate.

4. W-870

The Best Shotgun For Early Game.
W-870
StatsDescription
Power10.1 x2
Ammo Capacity10
Reload Speed0.95
Rate of Fire0.85
Precision2.80
  • Why I Chose This: W-870 is the first shotgun that you acquire and remains effective throughout the game with high stagger, good spread and the upgrade to double the dmg.
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W-870 is a powerful shotgun that shines when confronting hordes of Ganados, chainsaw-wielding adversaries, or the formidable El Gigante. The weapon is known for its tight spread and remarkable stopping power, enabling you to easily dispatch enemies.

  • While it may have the cheapest upgrades and lowest initial power of all shotguns, the Exclusive upgrade doubles its power, catapulting it to the top as the most potent shotgun in the game.
  • You must adapt to its slower rate of fire and reload speed, but these minor drawbacks are a small price to pay for the unparalleled power the W-870 shotgun delivers.
  • Can be acquired in the first chapter of the game.
  • The passive can double its power and has a high stagger DMG.
  • Has slow fire rate and reload speed throughout.
  • Outclassed by other shotguns in some scenarios.

5. Killer7

The Highest Base Dmg In Magnums.
Killer7
StatsDescription
Power28.0
Ammo Capacity15
Reload Speed1.40
Rate of Fire1.16
Precision2.50
  • Why I Chose This: Killer7 is an all-around best magnum due to its exceptional dmg and innate laser sight for accuracy, making it very versatile in many situations.
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Killer7 is a powerhouse magnum weapon that delivers devastating blows with each shot, swiftly eliminating adversaries with only a few well-aimed rounds. I must say, the Magnum’s immense firepower truly shines when facing more challenging opponents, such as the armored El Gigante and the daunting Krauser. Additionally, its piercing capabilities make it a prime choice for penetrating the tough exterior of specific enemies.

  • The limited ammo capacity may present a drawback.
  • The Killer7 Magnum’s unrivaled stopping power more than compensates for this minor shortcoming, solidifying its position as a formidable weapon in the game.
  • Deals insane DMG on every hit and has a crit buff.
  • Can stagger even the toughest of opponents.
  • Very high recoil and low ammo capacity.
  • Acquired very late in the main campaign.

6. Bolt Thrower

The Best Stealth Weapon In The Game.
Bolt Thrower
Power2.40
Ammo Capacity10 x2
Reload Speed0.94
Rate of Fire0.85
Precision3.00
  • Why I Chose This: Bolt Thrower is a unique weapon featuring a crossbow that launches exploding bolts that can deal AoE DMG and is very silent for stealthy approaches.
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Next up on the list I have the Bolt Thrower. It’s explosive bolts pack a powerful punch, inflicting significant damage and knockback to multiple enemies with a single shot. The weapon’s remarkable accuracy allows you to eliminate foes with pinpoint precision, even from a distance.

  • The bolts can blast, inflicting AoE DMG.
  • Is very silent, great for clearing multiple enemies.
  • It has a very low reload speed and fire rate.
  • Has low base dmg and ammo without upgrades.

7. Fighting Knife

The Best Knife In Resident Evil 4 Remake.
Fighting Knife
StatsDescription
Power1.80
Durability1.80
Attack Speed1.00
  • Why I Chose This: Fighting Knife would help you greatly in situations where you run out of ammo and packs a lot of punch against many smaller enemies.
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There are more potent weapons than the Fighting Knife. Yet I consider it a fantastic asset for any skilled player to have. Use the Fighting Knife in tandem with your other weapons to save bullets and provide devastating close-range damage to your foes. The Fighting Knife is surely one of the Resident Evil 4 Remake’s Best Melee Weapons, especially for sticky situations.

  • The Plague-infected villagers and Ganados are no match for its lightning-fast assault speed and stunning abilities.
  • The Fighting Knife also has other uses beyond combat, as it can be used to smash boxes and barrels to access valuable objects and ammunition.
  • Has very fast moveset along with high DMG.
  • Can also be utilized to open crates for ammo.
  • Obtained considerably late in the game.
  • Is a boss weapon, thus defeating the boss is necessary to obtain.

Alternative Weapons

Here are additional weapon options in Resident Evil 4 Remake to assist Leon in combating the Ganados threat and rescuing Ashley.

  • TMP: A submachine gun that delivers substantial damage, though its precision may be lacking compared to other options.
  • Broken Butterfly: Powerful magnum revolver that can take out enemies with just one shot.
  • Blacktail: Optimal for its balanced attributes of power, accuracy, and swift reload times, making it a reliable choice
  • Sentinel Nine: A highly accurate and versatile weapon, but it’s only available if you buy the Deluxe Edition of the game.

What I Think Is The Best Weapon

After having more than 50 hours in Resident Evil 4 Remake, my personal favorite handgun for the early game is Red9, due to the fact that aside from having devastating damage, you can quite literally obtain this weapon for free and sell their current handgun to upgrade the Red9 further. 

Both the Riot Gun Shotgun and the Striker Shotgun are fantastic weapons for damaging groups of enemies close to each other and are the weapons I frequently used in Resident Evil 4 whenever I was in a bind.

On the other hand, the Infinite ammo Chicago Sweeper and the Rocket Launcher are basically cheat codes that can make your playthrough a breeze.

This brings me to the end of my Resident Evil 4 Remake Best Weapons guide, where I have listed the best handguns, shotguns, SMGs, Rifles, knives, and more. What is your go-to weapon for crowd control and 1vs1 fights? Let me know more about it in the comments section below. Also, before you leave, consider reading my Resident Evil 4 Remake Review.

Update Log

This article was last updated on 12th July 2023

  • Information added: Added missing entries for SR M1903 and the Handcannon from RE4 Remake.
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Haris Umer is a Guides Writer on eXputer who can be seen torturing himself by playing FromSoftware’s offering of Souls games. He speaks about games with overwhelming passion, which readers can spot in his guides. Haris has been avidly playing video games for 15+ years now. You can learn more about his gaming experience through his PSN and Steam profiles.

Experience: 3+ Years || Education: Bachelors In Medicine And Surgery.

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