Resident Evil 4 Remake all bosses encounter contains a mixed bag of 10 unique and repeated fights. For instance, the Armored El Gigante will appear at least two times, which is repeated, but the encounter or scenario is unique. Understanding the attack patterns and how to defeat each boss in RE4 Remake will help you clear the game in good ranking, such as S+ & transition into NG+ smoothly.
- There are 10 unique boss fight encounters in Resident Evil 4 Remake.
- Del Lago: A ferocious creature that Leon encounters in a lake and must defeat while avoiding damage to his boat.
- El Gigante: A giant troll-like boss with a lot of health that Leon encounters in the Quarry area and must weaken by hitting its tentacle.
- Chainsaw Sisters: A boss duo that Leon must defeat by using grenades, positioning to use against Ganados, and avoiding parrying their attacks.
- Mendez: A towering, imposing boss with a spider-like transformation that Leon must defeat by staying mobile, utilizing resources, and stabbing him multiple times.
- Armored El Gigante: A puzzle-based encounter that requires players to dodge debris attacks and navigate the area’s hazards to reach a cannon located in a tower.
- Verdugo: Utilize freezing nitrogen traps, followed by powerful weapon attacks while it is temporarily incapacitated to overcome this agile and swift boss.
- Dos Gigantes: Target the unarmored El Gigante first with medium-range weapons and wait for Luis to throw dynamite to expose the armored giant’s weak point.
- Krauser: Employ strategic parrying and attacking techniques to overcome this formidable former U.S. Special Forces operative with exceptional combat skills.
- Ramon Salazar: Use automatic or semi-automatic firepower to shoot Salazar while he’s on the move, and take cover behind the staircase with a pillar to evade attacks.
- Osmund Saddler: Prioritize eliminating Novistadors, target the glowing eyes on Saddler’s limbs, and use a variety of weapons to deal damage and avoid his attacks.
Del Lago

Del Lago, a ferocious creature, is one of the earliest and most notable results of the twisted experiments carried out by Los Iluminados. What was first a harmless salamander, became the unwitting host of a parasitic organism that triggered a terrifying transformation resulting in the Del Lago creature. That being said, Leon first encountered the beast near the church, where he learned of its existence from a letter left for the ganado, warning them of its reawakening under the control of the infamous Prophet Saddler.
Attack Patterns

Attack Pattern | What You should do |
---|---|
Charges with open mouth | The most damaging attack that can be canceled with a harpoon throw. |
Emerges above the surface | Hit with harpoons, aim for the middle portion. |
Halt and submerge underwater | Be alert for reappearance and charge. |
Approaches boat | Hit the upper jaws or the center of the mouth to prevent boat damage. |
Other hindrances | Avoid debris and other obstacles. |
How To Defeat

- Avoid damaging your boat at all costs. Steer clear of any obstacles on the surface of the lake and keep steering left and right to increase your chances of dodging the monster’s attacks.
- When Del Lago charges at you with its mouth open, hit it in the mouth with a harpoon to cancel the attack and do the most damage.
- Keep throwing harpoons at the monster whenever it’s above the surface of the lake. Aim for the middle portion of its body to land a hit.
- Del Lago may go beneath, but it may resurface from anywhere and swim straight toward your boat.
- Avoid having the monster smash your boat by striking its top jaws or the middle of its mouth.
- In order to keep the boat from sinking, you should steer clear of any obstacles, such as floating trash, that may arise in the lake.
- Keep throwing harpoons until you spot Del Lago profusely bleeding, indicating that it’s close to death.
- Successfully defeating the Del Lago boss will earn you the Harpoon Hunter trophy/achievement, indicating the end of Chapter 3.
El Gigante

El Gigante is a boss in Resident Evil 4 Remake that Leon encounters in the Quarry area. It has a lot of health and is one of the most early-game challenging bosses. Gigante’s appearance reminisces of a troll or ogre, with large muscles and grayish-brown skin.
Attack Pattern

Phase | Attack Patterns |
---|---|
Phase 1 |
|
Phase 2 |
|
How To Defeat

- Save ammo and resources throughout the game, as El Gigante has a lot of health and can be difficult to defeat.
- In order to offer a useful diversion during the battle, it is necessary to free the dog that was previously kept in a bear trap outside the Village Chief’s House.
- Prioritize many headshots throughout phase 1 to do maximum damage to El Gigante. Evade under El Gigante’s legs if it gets too close, and be prepared to mash R2 and stab its hands if it grabs Leon with its tentacle attack.
- In phase 2, continue to deal damage to cause El Gigante to fall and expose its weak spot – a tentacle that players can melee through a prompt that shows up.
- Repeat this process until El Gigante is defeated and the Yellow Diamond item is collected to progress the story.
- Keep an eye out for crates around the arena, as El Gigante will break them, and they could contain herbs or ammo.
- Don’t forget to use healing items if necessary and make use of any explosive barrels or other environmental hazards in the arena to deal additional damage to El Gigante.
Chainsaw Sisters

In Resident Evil 4 Remake, you’ll face off against a boss duo known as the Bella Sisters, or the Chainsaw Sisters. Neither sister is impossible to beat, but they both provide significant difficulties for players just starting out. Rather than spend bullets on the easy-to-kill Ganados, it’s best to employ the Bella Sisters themselves to wipe out the swarm.
Attack Pattern

Attack Pattern | Description |
---|---|
Chainsaw Swing | Sisters swing their chainsaws horizontally. |
Chainsaw Lunge | Both bosses lunge forward with chainsaws. |
Chainsaw Charge | They charge at Leon with chainsaws. |
Team Attack | Sisters coordinate an attack together. |
Fodder Summon | They summon additional Ganados. |
How To Defeat

- Instruct Ashley to hide: Command Ashley to hide in a locker before the fight to focus on the boss without worrying about her safety.
- Use grenades: Begin the fight by throwing grenades at the Sisters, including flash grenades to stun them and follow up with melee attacks.
- Reposition to use Sisters against Ganados: Stand in a way that the Sisters hit the Ganados, helping clear them out and save ammunition.
- Avoid parrying chainsaw attacks: Parrying causes significant durability damage to the combat knife; instead, keep your distance and use firearms.
- Equip TMP or shotgun: Both weapons are effective against the Sisters; TMP can be purchased from the merchant in Chapter 3.
- Control the crowd: Thin out the horde of Ganados by using environmental hazards, choke points, or grenades to avoid being overwhelmed.
- Conserve ammo: Use the Sisters to eliminate Ganados, saving ammo for the boss fight.
- Focus on one Sister: Try to defeat one Sister first, making the fight more manageable.
- Maintain distance: Keep a safe distance to avoid their chainsaw attacks and take time to aim for headshots.
Mendez

Mendez, also known as the Village Chief, is a significant boss in the Resident Evil 4 Remake. As the leader of the rural village infected with the Las Plagas parasite, he oversees the villagers and enforces the will of the main antagonist, Osmund Saddler. Mendez is a towering, imposing figure who transforms into a monstrous, elongated creature with an elongated spine and additional limbs during the boss fight. Players face him in a slaughterhouse, where they must utilize strategy and quick thinking to overcome his various attack patterns and phases, ultimately defeating him and obtaining the crucial item, Mendez’s False Eye.
Attack Pattern

Attack Pattern | Description |
---|---|
Light Swings | Mendez swings at the player in his first phase. |
Exhausted State | He becomes briefly exhausted, allowing players to stab his weak spot. |
Spider Transformation | The boss transforms into a spider-like creature in phase two. |
Burning Wood Throw | Mendez throws large, burning pieces of wood at the player. |
Explosive Barrel Throw | He throws explosive barrels, which can be shot for extra damage. |
Charge Attack | Charges forward quickly to attack the player. |
How To Defeat

- Stay mobile in phase one: Keep moving around Mendez, focusing on his head and using the evade prompts for extra shots. Use the Riot Gun for effectiveness.
- Utilize resources: Search for crates containing gunpowder and resources during the first phase.
- Move to the upper floor in phase two: Gain a better angle on Mendez, who will throw items and charge forward.
- Shoot explosive barrels: When Mendez grabs explosive barrels, shoot them for additional damage.
- Avoid flaming boards: Run across the catwalk when Mendez throws flaming boards to dodge them.
- Counter rushing attack: Move to the opposite side of the walkway when Mendez charges, then switch to your shotgun or handgun and deal damage.
- Use flash grenades: They are effective in the second phase of the fight.
- Stab Mendez multiple times: You’ll need to knock him down and stab him at least two times to finish the fight.
- Collect Mendez’s False Eye: Obtain it after defeating him and search for any missed items before leaving the burning building.
Armored El Gigante

Armored El Gigante is a formidable boss in Resident Evil 4 Remake, found within Salazar Castle. As one of two armored El Gigante monsters, it serves to guard the upper sections of the castle. Out of Resident Evil 4 Remake all bosses encounters, this fight is more of a puzzle-based encounter, requiring players to dodge debris attacks and navigate the area’s hazards. Taking cover behind mobile shields or castle structures is vital to surviving the assault while also contending with cultists roaming the battlements.
- The ultimate goal is to reach a cannon located in a tower, maneuvering it into position while avoiding the boss’s relentless attacks.
- Once the cannon is aimed, lighting the fuse will deliver the final blow, defeating the Armored El Gigante.
Attack Pattern

Attack Pattern | Description |
---|---|
Debris Throw | Throws large debris at the player, requiring cover to dodge. |
Collateral Damage (Cultist Attack) | Cultists attack the player while dodging El Gigante’s moves. |
How To Defeat

- Utilize cover: Take cover behind mobile shields, boxes, or castle structures to avoid the debris thrown by Armored El Gigante.
- Time your movements: Move between cover and dodge attacks when the boss is not throwing debris or attacking.
- Eliminate cultists: Defeat cultists on the battlements while keeping an eye on the boss’s attacks.
- Follow the path: Progress through the level by following the wall, using dropdown sections, and reaching new towers.
- Use the lever: Find and pull the lever to alternate the moon and sun doors, creating new paths to advance.
- Shoot the weights: Ascend the second tower and shoot the weights holding down the cannon to position it for firing.
- Be patient: Don’t rush when rotating the cannon; wait for the right moment between the boss’s attacks to make adjustments.
- Deliver the final blow: Aim the cannon at the Armored El Gigante and light the fuse to defeat the boss with one shot.
Verdugo

Verdugo is a menacing boss in the Resident Evil 4 Remake, found in Chapter 10 within the underground laboratory’s sewer system. As one of Ramon Salazar’s right hands, this creature boasts a terrifying appearance with its insect-like features and exoskeleton. Known for its exceptional agility and swift attacks, Verdugo is a challenging adversary that requires strategic use of the environment to defeat. The key to overcoming this fearsome boss lies in using freezing nitrogen traps, followed by powerful weapon attacks while it is temporarily incapacitated.
Attack Pattern

Attack Pattern | Description |
---|---|
Claw Swipe | Verdugo swipes at Leon with its sharp claws. |
Lunge Attack | The boss lunges forward to strike Leon with its claws. |
Ceiling Drop | It drops down from the ceiling to surprise and attack Leon. |
Vent Ambush | Verdugo attacks Leon from the vents above, requiring evasive action. |
Stalking | The boss stalks Leon around the area, waiting for an opportunity to strike. |
How To Defeat

- Prepare powerful weapons: Equip shotguns, grenades, and a rocket launcher for dealing maximum damage to Verdugo.
- Use the environment: Activate panels around the tunnels to trigger freezing nitrogen, which will immobilize Verdugo.
- Time panel activation: Activate the panels a few seconds before Verdugo approaches to ensure the gas affects the boss.
- Attack when frozen: Unload your strongest weapons on Verdugo when it is incapacitated by the freezing nitrogen.
- Proceed with caution: After the first successful counterattack, crank the wheel to open the locked door and move to the next section while evading Verdugo’s vent attacks.
- Ensure the boss is following: Make sure Verdugo is actively following Leon before activating the next panel to avoid triggering the trap too early.
- Repeat the freezing process: It will likely take three freezes and plenty of firepower to defeat Verdugo on normal difficulty.
Dos Gigantes

Dos Gigantes are a pair of formidable El Gigante bosses found in Chapter 11 of Resident Evil 4 Remake. Encountered in the Blast Furnace, these two monsters consist of one armored and one unarmored giant, presenting a unique challenge for players. To defeat them, players must utilize a combination of evasion, firepower, and strategy.
- The unarmored El Gigante should be targeted first, with players employing medium-range weapons to inflict damage.
- The armored El Gigante, however, requires a different approach.
- Players must wait for Luis to throw dynamite, then shoot it to detonate and expose the creature’s weak point.
- By luring the weakened monster to the central part of the furnace and activating the hatch, players can ultimately triumph over the Dos Gigantes bosses.
Attack Pattern

Attack Pattern | Description |
---|---|
Ground Pound | Both giants slam the ground, causing shockwaves. |
Overhead Smash | A powerful downward smash targeting the player. |
Charge | A fast charge towards Leon, causing damage. |
Grab and Slam | The giant grabs the player and slams them down. |
Double Team | Both giants coordinate their attacks on Leon. |
Armored El Gigante’s Shield Bash | The armored giant uses its armor to bash the player. |
Unarmored El Gigante’s Backhand Swipe | The unarmored giant swipes at Leon with its hand. |
How To Defeat

- Prioritize the unarmored El Gigante first, as it is more vulnerable to attacks.
- Keep moving to avoid getting cornered or trapped by the giants.
- Use a shotgun or a medium-range weapon to attack the unarmored El Gigante.
- Focus on dodging and evading attacks from the armored El Gigante; don’t waste ammo on its armor.
- Once the parasite emerges on the unarmored El Gigante’s back, target it with gunfire.
- When the unarmored El Gigante kneels, perform a melee attack to climb and attack the parasite with a knife.
- Repeat the process of attacking the parasite until the first El Gigante is defeated.
- Wait for Luis to throw dynamite onto the armored El Gigante.
- Shoot the dynamite to detonate it when the armored giant is near the central furnace hatch.
- Quickly use the lever to open the large hatch in the furnace, causing the armored El Gigante to fall into the lava.
- Collect loot from the arena throughout the fight to replenish ammo and supplies.
Krauser

From our list of Resident Evil 4 Remake all bosses, Krauser is a formidable one, and he is encountered twice during the game in Chapters 11 and 14. A former U.S. Special Forces operative, Krauser was presumed dead before his appearance in RE4, where he serves as one of the antagonists. Now working for the mysterious Albert Wesker and the sinister Los Illuminados cult, Krauser’s primary goal is to obtain a sample of the powerful Las Plagas parasite.
Throughout the game, he engages in intense battles with the protagonist, Leon S. Kennedy, using his exceptional combat skills, cunning tactics, and a dangerous mutated arm. Players must employ strategic parrying and attacking techniques to overcome Krauser’s relentless onslaught and ultimately defeat him.
Attack Pattern

Chapter 11:
Attack Pattern | Description |
---|---|
Knife Slash | Basic knife attack |
Grab | Grabs and attempts to choke Leon |
Melee Combo | Quick melee combo |
Chapter 14:
Attack Pattern | Description |
---|---|
Knife Slash | Basic knife attack |
Grab | Grabs and attempts to choke Leon |
Melee Combo | Quick melee combo |
Gunfire | Shoots at Leon from a distance |
Mutated Arm Strike | Swings with a powerful mutated arm |
Mine Placement | Places mines in the area |
Grenade Throw | Throws grenades at Leon |
Aerial Slam | Jumps and slams down onto the arena |
How To Defeat

Chapter 11 Tips:
- Grab the Boot Knife at the beginning of the encounter.
- Focus on parrying Krauser’s attacks and counterattacking with your knife.
- Watch the knife symbol above your health bar to help with parry timing.
- If grabbed, use your knife to escape if low on health; otherwise, button mash.
Chapter 14 Tips:
- During the ruins fight, take cover behind debris and shoot Krauser with a long-range weapon.
- Engage in knife fights, focusing on parrying and counterattacks.
- Watch out for mines, bear traps, and turret cameras in the trap-filled section.
- In the boss arena fight, parry Krauser’s mutated arm strikes and use a shotgun or high-damage weapon to attack.
- Avoid Krauser’s slam attack by moving to the edge of the arena or climbing up a ladder.
- Consider using the Broken Butterfly Magnum if you’re struggling, but be mindful of limited ammo.
Upon defeating Krauser, you’ll obtain his Fighting Knife and possibly unlock the ‘You Used to Be a Good Guy’ Trophy or Achievement.
Ramon Salazar

Ramon Salazar is a challenging boss encountered in Chapter 12 of the Resident Evil 4 Remake. As the young and twisted castellan of the castle, he is deeply connected with the Los Illuminados cult and serves as a key antagonist. Salazar has merged with a monstrous creature, making him a formidable opponent in the game. Consider the Resident Evil 4 Remake all bosses; Salazar’s redesign & boss fight feels more underwhelming than the original 2005 version of the game.
Attack Pattern

Attack Pattern | Description |
---|---|
Acid Spit | Salazar’s monster spits acid at the player |
Acid Pods | Launches acid pods that can damage the player |
Chomp | The monster attempts to bite the player |
Ceiling Movement | Salazar moves across the ceiling to change position |
How To Defeat

- Get your hands on some automatic or semiautomatic firepower, like the TMP or Stingray, to make shooting Salazar simpler while he’s on the move.
- Have enough of healing supplies; Salazar’s assaults are lethal and may rapidly kill you if you’re unprepared.
- Shoot the monster when it spits acid: Focus on hitting Salazar’s body when the monster spits acid, as this is when he is vulnerable.
- Wait for the melee prompt: After inflicting enough damage, Salazar’s body will drop, allowing you to approach and deal melee damage.
- Take cover behind the staircase with a pillar: This position helps you effectively evade attacks like acid spit, acid pods, and the chomping attack.
- Shoot acid pods for loot: Acid pods drop useful items when shot, but keep your distance when they explode.
- Use the magnum or rifle for maximum damage: When Salazar’s body is exposed, use high-powered weapons to inflict significant damage.
- Stay in corners of the map: These spots can sometimes act as “safe zones” from Salazar’s ranged attacks.
- Consider using a Rocket Launcher: If you have the resources, a Rocket Launcher can deal massive damage and save you time and ammunition.
Osmund Saddler

Osmund Saddler is the primary antagonist and final boss in Resident Evil 4 Remake, serving as the leader of the Los Illuminados cult. Saddler is responsible for the Las Plagas parasite outbreak that plagues the game’s setting, using it to control villagers and other infected creatures in his quest for power.
Saddler’s ultimate goal is to infect high-ranking officials, including the U.S. President’s daughter, to extend his control on a global scale. In the final confrontation, Saddler mutates into a monstrous spider-like creature, showcasing his immense power and the horrifying effects of the Las Plagas parasite.
Attack Pattern

Attack Pattern | Description |
---|---|
Swipe | Saddler swipes with claws; run or keep distance to evade. |
Debris Throw | Climbing on beams, Saddler throws debris; you should dodge to avoid it. |
Jump Attack | The boss jumps on Leon; watch for prompts to evade. |
Corrosive Spit | He vomits corrosive spit; you must dodge to avoid it. |
Limb Slam | Saddler slams sharp limbs; move around to avoid. |
Minion Summon | The boss summons Novistadors; you should eliminate them quickly. |
Red Explosive Barrels | Shoot barrels when Saddler is close to stun and deal damage. |
Mutated Tendril Trap (Final Stage) | Trapped by tendrils, damage remaining eyes before time runs out. |
How To Defeat

- Prioritize eliminating Novistadors: They can swarm and distract you; take them out quickly to focus on Saddler.
- Target glowing eyes on Saddler’s limbs: Damaging all eyes will make him stumble, allowing you to melee or shoot the eye on his head.
- Keep moving and evading: Watch for prompts to avoid Saddler’s swipes, debris throws, jumps, and corrosive spit.
- Loot the area early: Saddler gradually destroys the arena, limiting space and access to resources; collect items early if needed.
- Use a variety of weapons: Fully upgraded pistols, shotguns, and rifles with Biosensor Scope are effective at different distances and situations.
- Utilize grenades for extra damage: Use Hand Grenades or Mines to stagger Saddler when he’s on the ground.
- Aim for explosive barrels: Shoot red barrels near Saddler to deal damage and momentarily stun him.
- Focus on remaining eyes in the final stage: When Saddler traps you with his tendrils, you must quickly damage his remaining eyes.
- Use Ada’s rocket launcher for the final hit: Aim carefully to avoid missing, as Saddler can kill Leon if you miss the shot.
Final Remarks
This brings us to the end of our Resident Evil 4 Remake all bosses guide, where we have given insights regarding boss attack patterns, tips, strategies, and how to defeat each one of them in the game. Before you leave the page, read our Resident Evil 4 Remake: How To Get Thermal Scope, Jewel Thief, and How To Unlock Cat Ears guides.
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